HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-(3-Fluorophenyl)-5-methylisoxazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 70981314 | HCID 70981314 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(3-Fluorophenyl)-5-methylisoxazole-4-carboxylic acid | HCID 23447882 | 92% |
Reaction Steps
In a similar manner as described in Preparation Example 25, by using methanol (60 mL), methyl-3-(3-fluorophenyl)-5-methylisoxazol-4-carboxylate (6.0 g, 25.51 mmol) and 3% sodium hydroxide aqueous solution (60 mL), a white solid required compound (5.21 g, 23.44 mmol, 92%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09132126B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-b566705dec074fdd83da69c12ab9f4ed |
| Source note | uspto-grants-2015_09 |