Sodium Hydroxide → HCID 70980447, compound

HRID 2276414Notes

Reaction equation

HRID 2276414 reaction equation
C[O:2][C:3]([C:5]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][C:18]([F:21])([F:20])[F:19])[CH:12]=2)=[N:7][O:8][C:9]=1[CH3:10])=[O:4].[OH-].[Na+]>CO>[CH3:10][C:9]1[O:8][N:7]=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][C:18]([F:21])([F:19])[F:20])[CH:12]=2)[C:5]=1[C:3]([OH:4])=[O:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 70982049HCID 70982049, compound

Product 1

HCID 70980447HCID 70980447, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described in Preparation Example 25, by using methanol (60 mL), methyl-5-methyl-3-(3-(trifluoromethoxy)phenyl)isoxazol-4-carboxylate (6.0 g, 19.91 mmol) and 3% sodium hydroxide aqueous solution (60 mL), a white solid required compound (5.47 g, 19.04 mmol, 96%) was obtained.

Workup

  1. customIn a similar manner as described in Preparation Example 25

Sources & evidence

ORD record
ord-8695e24576a24f3e92bc3ebb0523d09c
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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