Methyl cyanoacetate → HCID 28473083, compound

HRID 2276416Notes

Reaction equation

HRID 2276416 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4](Cl)=[N:5][OH:6].[CH3:12][O:13][C:14](=[O:18])[CH2:15][C:16]#[N:17].C[O-].[Na+]>CO>[CH3:12][O:13][C:14]([C:15]1[C:4]([C:3]2[CH:8]=[CH:9][CH:10]=[CH:11][C:2]=2[Cl:1])=[N:5][O:6][C:16]=1[NH2:17])=[O:18]

Participants

5

Reactant 3

HCID 7747Methyl cyanoacetateHCID 380973329568-74-9HCID 10942334Sodium Methoxide

Product 1

HCID 28473083HCID 28473083, compoundYield 88.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described in Preparation Example 17, by using methanol (160 mL), 2-chloro-N-hydroxybenzimidoylchloride (8.00 g, 42.10 mmol), methylcyanoacetate (5.22 g, 52.63 mmol) and sodium methoxide (4.55 g, 84.20 mmol), a white solid required compound (9.40 g, 37.21 mmol, 88%) was obtained.

Workup

  1. customIn a similar manner as described in Preparation Example 17

Sources & evidence

ORD record
ord-b64565e58b2041b2a13168aa9d8bb4ff
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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