Methyl cyanoacetate → HCID 70981025, compound

HRID 2276419Notes

Reaction equation

HRID 2276419 reaction equation
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]([F:14])([F:13])[F:12])=[CH:6][CH:5]=1.[CH3:16][O:17][C:18](=[O:22])[CH2:19][C:20]#[N:21].C[O-].[Na+]>CO>[NH2:21][C:20]1[O:1][N:2]=[C:3]([C:4]2[CH:9]=[CH:8][C:7]([O:10][C:11]([F:14])([F:13])[F:12])=[CH:6][CH:5]=2)[C:19]=1[C:18]([O:17][CH3:16])=[O:22]

Participants

5

Reactant 3

HCID 7747Methyl cyanoacetateHCID 10942334Sodium MethoxideHCID 86210273HCID 86210273, compound

Product 1

HCID 70981025HCID 70981025, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described in Preparation Example 17, by using methanol (160 mL), N-hydroxy-4-(trifluoromethoxy)benzimidoylchloride (8.00 g, 33.39 mmol), methylcyanoacetate (4.31 g, 43.41 mmol) and sodium methoxide (3.61 g, 66.78 mmol), a white solid required compound (8.27 g, 27.35 mmol, 82%) was obtained.

Workup

  1. customIn a similar manner as described in Preparation Example 17

Sources & evidence

ORD record
ord-00118177ff0f4c778e26c5a40c1f052c
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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