Methyl cyanoacetate → HCID 70981646, compound

HRID 2276420Notes

Reaction equation

HRID 2276420 reaction equation
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[O:10][C:11]([F:14])([F:13])[F:12].[CH3:16][O:17][C:18](=[O:22])[CH2:19][C:20]#[N:21].C[O-].[Na+]>CO>[NH2:21][C:20]1[O:1][N:2]=[C:3]([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[O:10][C:11]([F:14])([F:13])[F:12])[C:19]=1[C:18]([O:17][CH3:16])=[O:22]

Participants

5

Reactant 3

HCID 7747Methyl cyanoacetateHCID 10942334Sodium MethoxideHCID 76657799HCID 76657799, compound

Product 1

HCID 70981646HCID 70981646, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described in Preparation Example 17, by using methanol (160 mL), N-hydroxy-2-(trifluoromethoxy)benzimidoylchloride (8.00 g, 33.39 mmol), methylcyanoacetate (4.31 g, 43.41 mmol) and sodium methoxide (3.61 g, 66.78 mmol), a white solid required compound (9.07 g, 30.02 mmol, 90%) was obtained.

Workup

  1. customIn a similar manner as described in Preparation Example 17

Sources & evidence

ORD record
ord-ffd81fabaac446f8bd0dccf47120c6de
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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