Sodium Hydroxide → HCID 70981175, compound

HRID 2276428Notes

Reaction equation

HRID 2276428 reaction equation
C[O:2][C:3]([C:5]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][C:18]([F:21])([F:20])[F:19])=[N:7][O:8][C:9]=1[NH2:10])=[O:4].[OH-].[Na+]>CO>[NH2:10][C:9]1[O:8][N:7]=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][C:18]([F:20])([F:21])[F:19])[C:5]=1[C:3]([OH:4])=[O:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 70981646HCID 70981646, compound

Product 1

HCID 70981175HCID 70981175, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described in Preparation Example 25, by using methanol (60 mL), methyl-5-amino-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-carboxylate (6.0 g, 19.85 mmol) and 3% sodium hydroxide aqueous solution (60 mL), a white solid required compound (4.00 g, 13.89 mmol, 70%) was obtained.

Workup

  1. customIn a similar manner as described in Preparation Example 25

Sources & evidence

ORD record
ord-599f48b4232b4d8fb774c83d197eed27
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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