Sodium Hydroxide → HCID 70981307, compound

HRID 2276429Notes

Reaction equation

HRID 2276429 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=2)[C:3]=1[C:17]([O-:19])=[O:18].[OH-].[Na+]>CO>[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=2)[C:3]=1[C:17]([OH:19])=[O:18]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86709608HCID 86709608, compound

Product 1

HCID 70981307HCID 70981307, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described in Preparation Example 25, by using methanol (60 mL), 5-amino-3-(3-(trifluoromethyl)phenyl)isoxazol-4-carboxylate (6.0 g, 20.96 mmol) and 3% sodium hydroxide aqueous solution (60 mL), a white solid required compound (4.14 g, 15.21 mmol, 73%) was obtained.

Workup

  1. customIn a similar manner as described in Preparation Example 25

Sources & evidence

ORD record
ord-78816c5920784cf2b5994e5334a0889a
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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