1-(2-Fluorophenyl)piperazine → HCID 66576698, compound

Participants

Reaction Steps

5-methyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-carboxylic acid (500 mg, 1.84 mmol), 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride (388 mg, 2.02 mmol) and 1-(2-fluorophenyl)piperazine (332 mg, 1.84 mmol) were dissolved in dichloromethane (30 mL), and stirred at room temperature for 8 hours. The resultant solution was washed with saturated sodium carbonate aqueous solution (30 mL), purified water (30 mL) and saturated sodium chloride aqueous solution (30 mL), respectively. Then, the organic layer was dried with anhydrous sodium sulfate, concentrated, and purified with column chromatography so as to provide a white solid required compound (528 mg, 1.34 mmol, 73%).

Provenance & Evidence