HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3,4-Dichlorophenyl)piperazine → (4-(3,4-Dichlorophenyl)piperazine-1-yl)(3-(2-fluorophenyl)-5-methylisoxazol-4-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3,4-Dichlorophenyl)piperazine | HCID 93601 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 3-(2-Fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid | HCID 6484101 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (4-(3,4-Dichlorophenyl)piperazine-1-yl)(3-(2-fluorophenyl)-5-methylisoxazol-4-yl)methanone | HCID 66576940 | 74% |
Reaction Steps
In a similar manner as described in Example 1, by using dichloromethane (30 mL), 3-(2-fluorophenyl)-5-methylisoxazol-4-carboxylic acid (407 mg, 1.84 mmol), 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride (388 mg, 2.02 mmol) and 1-(3,4-dichlorophenyl)piperazine (425 mg, 1.84 mmol), a white solid required compound (587 mg, 1.35 mmol, 74%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09132126B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-38ca2cce7b8b421b9a5437e35f8ad2a2 |
| Source note | uspto-grants-2015_09 |