HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(3-methoxyphenyl)piperazine → (3-(2-Fluorophenyl)-5-methylisoxazol-4-yl)(4-(3-methoxyphenyl)piperazine-1-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(3-methoxyphenyl)piperazine | HCID 81430 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 3-(2-Fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid | HCID 6484101 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (3-(2-Fluorophenyl)-5-methylisoxazol-4-yl)(4-(3-methoxyphenyl)piperazine-1-yl)methanone | HCID 66576941 | 86% |
Reaction Steps
In a similar manner as described in Example 1, by using dichloromethane (30 mL), 3-(2-fluorophenyl)-5-methylisoxazol-4-carboxylic acid (407 mg, 1.84 mmol), 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride (388 mg, 2.02 mmol) and 1-(3-methoxyphenyl)piperazine (354 mg, 1.84 mmol), a white solid required compound (622 mg, 1.57 mmol, 86%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09132126B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-6e20739303544a8cb9570726b6f1711c |
| Source note | uspto-grants-2015_09 |