HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3,4-Dichlorophenyl)piperazine → (5-Amino-3-(2-fluorophenyl)isoxazol-4-yl)(4-(3,4-dichlorophenyl)piperazine-1-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3,4-Dichlorophenyl)piperazine | HCID 93601 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 5-Amino-3-(2-fluorophenyl)isoxazol-4-carboxylic acid | HCID 70981218 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (5-Amino-3-(2-fluorophenyl)isoxazol-4-yl)(4-(3,4-dichlorophenyl)piperazine-1-yl)methanone | HCID 66576306 | 81% |
Reaction Steps
In a similar manner as described in Example 1, by using dichloromethane (30 mL), 5-amino-3-(2-fluorophenyl)isoxazol-4-carboxylic acid (409 mg, 1.84 mmol), 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride (388 mg, 2.02 mmol) and 1-(3,4-dichlorophenyl)piperazine (425 mg, 1.84 mmol), a white solid required compound (613 mg, 1.49 mmol, 81%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09132126B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-aafed3ed95c14b468d1682c5fb0129b5 |
| Source note | uspto-grants-2015_09 |