Sodium Chloride → HCID 63199034, compound

HRID 227649Notes

Reaction equation

HRID 227649 reaction equation
[Cl:1][C:2]1[C:3]([CH:12]([C:17](=[O:20])[CH2:18][CH3:19])C(OC)=O)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[Cl-].[Na+]>O.CS(C)=O>[Cl:1][C:2]1[C:3]([CH2:12][C:17](=[O:20])[CH2:18][CH3:19])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

Participants

5

Reactant 2

HCID 5234Sodium ChlorideHCID 23078246HCID 23078246, compound

Product 1

HCID 63199034HCID 63199034, compound

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 962WaterSolvent2×

Conditions

Temperature
130 °C

Procedure

2.08 g of methyl 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-3-oxopentanoate (0.00677 mol) and 0.12 g of sodium chloride are dissolved in a mixture of water (0.25 mL) and dimethylsulfoxyde (20 mL). The reaction medium is stirred at a temperature of 130° C. for 8 hours. After cooling, 100 mL of water are added to the reaction mixture which is extracted twice with 150 mL of ethyl acetate.

Workup

  1. temperatureAfter cooling
  2. extractionis extracted twice with 150 mL of ethyl acetate

Sources & evidence

ORD record
ord-752b4e9ea8b046e4b5d8ac9200aa395b
Source dataset
uspto-grants-2009_07
Patent number
US07560567B2

Reaction notes

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