HuagongsheHuagongshe Chemistry Print Report · For research reference only
o-(1-Piperazinyl)phenol → HCID 66576459, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | o-(1-Piperazinyl)phenol | HCID 70530 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 70982325 | HCID 70982325 | — |
| Reactant | HCID 178418300 | HCID 178418300 | — |
| Product | HCID 66576459 | HCID 66576459 | 71.2% |
Reaction Steps
In a similar manner as described in Example 1, by using dimethylformimide (15 mL), 5-amino-3-(3-(trifluoromethoxy)phenyl)isoxazol-4-carboxylic acid (530 mg, 1.84 mmol), 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride (388 mg, 2.02 mmol), hydroxybenzotriazole (299 mg, 2.21 mmol) and 2-(piperazine-1-yl)phenol (328 mg, 1.84 mmol), a white solid required compound (588 mg, 1.31 mmol, 71%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09132126B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-2c9640c4795f4e669e15b5eebc2ed930 |
| Source note | uspto-grants-2015_09 |