Ethanol → HCID 70980597, compound

HRID 2276507Notes

Reaction equation

HRID 2276507 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[Cl:13])[C:3]=1[C:14]([N:16]1[CH2:21][CH2:20][N:19]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=2)[CH2:18][CH2:17]1)=[O:15].C(O)C>CC(C)=O>[ClH:13].[NH2:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[Cl:13])[C:3]=1[C:14]([N:16]1[CH2:17][CH2:18][N:19]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=2)[CH2:20][CH2:21]1)=[O:15]

Participants

4

Reactant 2

HCID 702EthanolHCID 66576696HCID 66576696, compound

Product 1

HCID 70980597HCID 70980597, compoundYield 140%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

In a similar manner as described in Example 126, by using acetone (10 mL), (5-amino-3-(2-chlorophenyl)isoxazol-4-yl)(4-(3-methoxyphenyl)piperazine-1-yl)methanone (83 mg, 0.20 mmol) and hydrochloric ethanol (10%, 73 mg, 0.20 mmol), a white solid required compound (63 mg, 0.14 mmol, 70%) was obtained.

Sources & evidence

ORD record
ord-21548719cbe844dab80dd00b242dd4c4
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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