Hydrochloric Acid → HCID 66665960, compound

Participants

Reaction Steps

Enantiomer 2 of methyl 6-(1-methyl-6,7-diphenyl-1,2,3,4-tetrahydro-1,8-naphthyridin-2-yl)hexanoate (34 mg, 0.079 mmol) was dissolved in THF/water (2:1) and lithium hydroxide (9.99 mg, 0.238 mmol) was added. The reaction mixture was stirred vigorously at room temperature for 48 h and then diluted with water (20 ml). The pH was adjusted to pH 3-4 by addition of 2M HCl. The aqueous portion was extracted with DCM (3×30 ml) and the combined organic extracts were washed with brine, dried over MgSO4, filtered and concentrated in vacuo to afford the title compound as a yellow oil;

Provenance & Evidence