HCID 86681849, compound → HCID 66665673, compound

Participants

Reaction Steps

A solution of (E)-ethyl 8-(2,3-dip-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)oct-2-enoate (step 1)(60 mg, 0.124 mmol) and 10% Pd/C (66.0 mg, 0.062 mmol) in MeOH (10 ml) placed under an atmosphere of hydrogen at 0.35 bar pressure and stirred at room temperature overnight. The mixture was filtered through Celite® (filter material) and washed through with MeOH. The filtrated was concentrated in vacuo and purification of the crude product by chromatography on silica eluting with iso-hexane/EtOAc afforded the title compound as a pale yellow oil;

Provenance & Evidence