2,3-Diaminopyridine → HCID 86681857, compound

HRID 2276592Notes

Reaction equation

HRID 2276592 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:8]=[CH:7][C:6]([C:9](=O)[C:10]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)=O)=[CH:5][CH:4]=1.[N:25]1[CH:30]=[CH:29][CH:28]=[C:27]([NH2:31])[C:26]=1[NH2:32]>>[F:1][C:2]([F:24])([F:23])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:31]=[C:27]3[CH2:28][CH2:29][CH2:30][NH:25][C:26]3=[N:32][C:10]=2[C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 99562,3-DiaminopyridineHCID 5993781,2-bis[4-(trifluoromethyl)phenyl]ethane-1,2-dione

Product 1

HCID 86681857HCID 86681857, compound

Procedure

The title compound was prepared from 1,2-bis(4-(trifluoromethyl)phenyl)ethane-1,2-dione (this may be prepared according to the procedure of Bioorganic & Medicinal Chemistry Letters (2007), 17(21), 5825-5830) and pyridine-2,3-diamine analogously to Intermediate E;

Workup

  1. customthis may be prepared

Sources & evidence

ORD record
ord-027f59233fca4fa5b9bbcf287dbd198d
Source dataset
uspto-grants-2015_09
Patent number
US09132127B2

Reaction notes

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