1,4-Dioxane → (R)-2,3-diphenyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-8-yl acetate

Participants

Reaction Steps

A solution of (R)-tert-butyl 8-acetoxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate (62 mg, 0.139 mmol) in 4M HCl in dioxane (1.252 ml, 5.01 mmol) was left to stir under an atmosphere of nitrogen for 1 hour. The reaction mixture was concentrated in vacuo to afford (R)-2,3-diphenyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazin-8-yl acetate (Intermediate HBR) which was used without further purification.

Provenance & Evidence