反应详情

7-Methoxy-2,3-dip-tolylpyrido[2,3-b]pyrazine (94 mg, 0.275 mmol) in dry MeOH (4 ml), under nitrogen was treated with 10% Pd on Carbon (58.6 mg, 0.056 mmol). The suspension was stirred at RT under an atmosphere of hydrogen for 32 hours. The resulting mixture was loaded onto a 2.5 g Celite® column using MeOH and was flushed with 1:1 MeOH:DCM. The filtrate was concentrated in vacuo and the residue was dissolved in DCM (30 ml) and washed with water (×2). The organic portion was isolated and the solvent was removed in vacuo to afford the title compound;

1. customwas flushed with 1:1 MeOH
2. concentrationThe filtrate was concentrated in vacuo
3. dissolutionthe residue was dissolved in DCM (30 ml)
4. washwashed with water (×2)
5. customThe organic portion was isolated
6. customthe solvent was removed in vacuo