Potassium Carbonate → 2-(6-Fluoro-1H-benzimidazol-1-yl)-4-({[2-(trifluoromethyl)phenyl]methyl}oxy)-1,3-thiazole-5-carboxamide

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Reaction Steps

Following the procedure described above for the preparation of 2-(1H-benzimidazol-1-yl)-4-({[2-(trifluoromethyl)phenyl]methyl}oxy)-1,3-thiazole-5-carboxamide using the following materials: 2-chloro-4-({[2-(trifluoromethyl)phenyl]methyl}oxy)-1,3-thiazole-5-carboxamide (0.050 g, 0.14 mmol), 5-fluorobenzimidazole (0.011 g, 0.08 mmol), K2CO3 (0.011 g, 0.08 mmol) and DMF (4 mL). Data for 6 regioisomers: 1H NMR (400 MHz, CDCl3) δ 8.46 (s, 1H), 7.82-7.74 (m, 2H), 7.69-7.58 (m, 3H), 7.54-7.50 (m, 1H), 7.16 (td, J=9.1, 2.4 Hz, 1H), 6.80 (bs, 1H), 5.82 (s, 2H), 5.76 (bs, 1H). MS m/z 437 (m+1).

Provenance & Evidence