Potassium Carbonate → HCID 11386033, 화합물

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The title compound was prepared in a manner analogous to the procedure described above for the preparation of 2-(1H-benzimidazol-1-yl)-4-({[2-(trifluoromethyl)phenyl]methyl}oxy)-1,3-thiazole-5-carboxamide, using the following materials: 2-chloro-4-({[2-(trifluoromethyl)phenyl]methyl}oxy)-1,3-thiazole-5-carboxamide (0.146 g, 0.434 mmol), 5,6-dimethoxybenzimidazole (0.0851 g, 0.478 mmol), K2CO3 (0.0720 g, 0.521 mmol) and DMF (4 mL). Flash chromatography afforded 0.114 g (55%) of the title compound. 1H NMR (400 MHz, DMSO-d6) δ 8.75 (s, 1H), 7.87-7.73 (m, 4H), 7.61 (m, 1H), 7.61 (s, 1H), 7.37 (s, 1H), 6.94 (br s, 1H), 5.85 (s, 2H), 3.83 (s, 3H), 3.72 (s, 3H). MS m/z 479 (m+1).

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