Sodium Hydroxide → HCID 20760031, compound

HRID 2276671Notes

Reaction equation

HRID 2276671 reaction equation
[CH3:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:12](=[O:18])[CH2:13][CH2:14][C:15]([OH:17])=[O:16])[CH:9]=[CH:10][CH:11]=1.[OH-].[Na+:25]>C(O)C>[Na+:25].[CH3:23][C:19]1[CH:20]=[CH:21][CH:22]=[C:2]([CH3:1])[C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:12](=[O:18])[CH2:13][CH2:14][C:15]([O-:17])=[O:16])[CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 9926783HCID 9926783, compound

Product 1

HCID 20760031HCID 20760031, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The 4-(3-(2,6-Dimethylbenzyloxy)phenyl)-4-oxobutyric acid (Step D, 5.5 g, 17.6 mmol) was dissolved in abs ethanol (20 ml) by warming gently followed by addition of NaOH (0.705 g) at 0° C. temperature. The reaction mixture was stirred for one hour, concentrated in vaccuo and lyophilized to give as a white solid.

Workup

  1. temperatureby warming gently
  2. concentrationconcentrated in vaccuo
  3. customto give as a white solid

Sources & evidence

ORD record
ord-65df0a1a70024ebb86a29a5a1b65c2ab
Source dataset
uspto-grants-2015_09
Patent number
US09133073B2

Reaction notes

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