反应详情

温度

80 °C

To a solution of diethyl heptanedioate (65 g, 0.30 mol) in Ethanol (400 mL) was added KOH (16.8 g, 0.30 mmol). The mixture was stirred at 80° C. for 24 hours, and concentrated under reduced pressure. The resulting mixture was poured into water and the pH value of the solution was adjusted to 1 by concentrated H2SO4. After removal of the solvent, the crude product was purified by flash chromatography SiO2(EtOH:EtOAc=1:10) to give the desired compound (38 g, yield 67%).

1. concentrationconcentrated under reduced pressure
2. additionThe resulting mixture was poured into water
3. customAfter removal of the solvent
4. customthe crude product was purified by flash chromatography SiO2(EtOH:EtOAc=1:10)