Hydrochloric Acid → HCID 86697405, compound

Participants

Reaction Steps

HCl (g) was bubbled through a solution of tert-butyl 6-((3,4-dichlorophenyl)(ethoxyimino)methyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate (100 mg, 0.25 mmol) obtained in step-2 of example 1 in dry DCM (5 mL). After the completion of the reaction as confirmed by TLC, the reaction mixture was purged with excess of nitrogen. The solvent was removed in vacuo to afford a gummy solid which was titurated with hexane to afford hydrochloric acid salt of 3-azabicyclo[3.1.0]hexan-6-yl(3,4-dichlorophenyl)methanone O-ethyl oxime (75 mg, 86%) as a white solid as a mixture of isomers.

Provenance & Evidence