Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

HCl (g) was bubbled through a solution of tert-butyl 6-((3,4-dichlorophenyl)(phenoxyimino)methyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate (160 mg, 0.36 mmol) obtained in step-1 of example 2 in dry DCM (5 mL). After the completion of the reaction as confirmed by TLC, the reaction mixture was purged with excess of nitrogen. The solvent was removed in vacuo to afford hydrochloric acid salt of 3-azabicyclo[3.1.0]hexan-6-yl(3,4-dichlorophenyl)methanone O-phenyl oxime as a gummy solid which was titurated with hexane to afford (125 mg, 91%) as a white solid as a mixture of isomers.

Provenance & Evidence