Potassium Carbonate → HCID 54590828, compound

Participants

Reaction Conditions

Reaction Steps

To a 3 mL microwave reaction vessel was added 4-bromo-N-(1-phenylcyclobutyl)pyridin-2-amine (50 mg, 165 μmol, 1.0 equiv), phenylboronic acid (30 mg, 248 μmol, 1.5 equiv), Cl2Pd(dppf) (12 mg, 16 μmol, 0.1 equiv), potassium carbonate (57 mg, 413 μmol, 2.5 equiv), dioxane (750 μL), and water (250 μL). The reaction was heated in a microwave reactor at 140° C. for 20 min and then diluted with saturated sodium bicarbonate (20 mL) and extracted with ethyl acetate (50 mL). The organic layer was then dried over Na2SO4, filtered, and concentrated to give a crude solid that was purified by reverse phase column chromatography to afford 9 mg of 4-phenyl-N-(1-phenylcyclobutyl)pyridin-2-amine (m/z [M+H]=301.2).

Provenance & Evidence