Potassium Carbonate → HCID 54590830, compound

Participants

Reaction Conditions

Reaction Steps

To a 3 mL microwave reaction vessel was added 5-bromo-N-(1-phenylcyclobutyl)pyridin-2-amine (102 mg, 340 μmol, 1.0 equiv), phenylboronic acid (59 mg, 505 μmol, 1.5 equiv), Cl2Pd(dppf) (25 mg, 34 μmol, 0.1 equiv), potassium carbonate (116 mg, 842 μmol, 2.5 equiv), dioxane (1 mL) and water (500 μL). The reaction was heated in a microwave reactor at 140° C. for 20 min and then diluted with saturated sodium bicarbonate (20 mL) and extracted with ethyl acetate (50 mL). The organic layer was then dried over Na2SO4, filtered, and concentrated to give a crude solid that was purified by silica gel column chromatography (10% EtOAc/hexanes), affording 27 mg of 5-phenyl-N-(1-phenylcyclobutyl)pyridin-2-amine as a white solid (m/z [M+H]=301.2).

Provenance & Evidence