HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-((1R)-((2R,4R,5S)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methoxy)-4-((1R)-((2R,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methoxy)phthalazine → HCID 71572205, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-((1R)-((2R,4R,5S)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methoxy)-4-((1R)-((2R,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methoxy)phthalazine | HCID 51003674 | — |
| Reactant | HCID 71572206 | HCID 71572206 | — |
| Product | HCID 71572205 | HCID 71572205 | — |
Reaction Steps
(S)-4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)pyrimidine-2-carboxamide (Compound Example No. 21) was prepared in a similar fashion to (R)-4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)pyrimidine-2-carboxamide (Compound Example No. 20) using AD-Mix-α instead of AD-Mix-β. 1H NMR (400 MHz, CD3OD): 8.25 (2H, d, J=8.8 Hz), 8.09 (1H, s), 7.09-6.98 (6H, m), 4.75 (1H, m), 4.10 (1H, dd, J=3.6, 12 Hz), 3.77 (1H, dd, J=5.2, 12 Hz); LC/MS: m/z=370[M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133131B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-985d6d1dc1a44e7983c0584b496552a0 |
| Source note | uspto-grants-2015_09 |