HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → HCID 89582603, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | HCID 71572205 | HCID 71572205 | — |
| Reactant | HCID 89580281 | HCID 89580281 | — |
| Product | HCID 89582603 | HCID 89582603 | 80% |
Reaction Steps
(S)-6-(1,2-dihydroxyethyl)-2-(4-(4-fluorophenoxy)phenyl)pyrimidine-4-carboxylic acid (25) was prepared in a similar fashion to compound 20 (Scheme 3) using AD mix-α (1.51 g) and compound 24 (360 mg, 1.03 mmol) in aqueous isopropyl alcohol (i-PrOH:H2O=1:1). (304 mg, 80% yield); LC/MS: m/z=371[M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133131B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-f002125da5ca431587850b34489c6e1e |
| Source note | uspto-grants-2015_09 |