1-((1R)-((2R,4R,5S)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methoxy)-4-((1R)-((2R,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methoxy)phthalazine → HCID 71572100, compound

Participants

Reaction Steps

(S)-2-(4-(4-cyano-3-(trifluoromethyl)phenoxy)phenyl)-6-(1,2-dihydroxyethyl) pyrimidine-4-carboxamide (Compound Example No. 13) was prepared in a similar fashion to (R)-2-(4-(4-cyano-3-(trifluoromethyl) phenoxy)phenyl)-6-(1,2-dihydroxy-ethyl)pyrimidine-4-carboxamide (Compound Example No. 12) using AD-Mix alpha instead of AD-Mix beta. 1H NMR (400 MHz, DMSO-d6) δ 8.80-8.70 (2 H, m), 8.69-8.61 (1 H, m), 8.23-8.15 (1 H, m), 8.07-8.02 (1 H, m), 8.01-7.96 (1 H, m), 7.67-7.60 (1 H, m), 7.49-7.41 (1 H, m), 7.42-7.34 (2 H, m), 5.86-5.78 (1 H, m), 4.87-4.79 (1 H, m), 4.75-4.66 (1 H, m), 3.85-3.76 (1 H, m), 3.74-3.63 (1 H, m); LC/MS: m/z=445 [M+H]+.

Provenance & Evidence