HCID 66806437, compound → HCID 71572208, compound

Participants

Reaction Steps

(R)-6-(1,2-dihydroxyethyl)-2-(4-(4-(trifluoromethyl)phenoxy)phenyl) pyrimidine-4-carboxamide (Compound Example No. 18) was prepared a similarly to (R)-2-(4-(4-cyano-3-(trifluoromethyl)phenoxy)phenyl)-6-(1,2-dihydroxyethyl) pyrimidine-4-carboxamide (Compound Example No. 12) using 4,4,5,5-tetramethyl-2-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,3,2-dioxaborolane. 1H NMR (400 MHz, DMSO-d6): 8.75-8.67 (2 H, m), 8.65-8.59 (1 H, m), 8.05-8.01 (1 H, m), 8.01-7.94 (1 H, m), 7.83-7.75 (2 H, m), 7.31-7.22 (4 H, m), 5.84-5.79 (1 H, m), 4.87-4.79 (1 H, m), 4.73-4.67 (1 H, m), 3.86-3.77 (1 H, m), 3.74-3.64 (1 H, m); LC/MS: m/z=420 [M+H]+.

Provenance & Evidence