2-Cyclopenten-1-one → HCID 67296469, compound

HRID 2276843Notes

Reaction equation

HRID 2276843 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12](B(O)O)=[CH:11][C:10]=1[F:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19]1(=[O:24])[CH2:23][CH2:22][CH:21]=[CH:20]1>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C@@H:21]2[CH2:22][CH2:23][C:19](=[O:24])[CH2:20]2)=[CH:11][C:10]=1[F:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 135882-Cyclopenten-1-oneHCID 27377884-Benzyloxy-3-fluorophenylboronic Acid

Product 1

HCID 67296469HCID 67296469, compoundYield 68.6%

Procedure

[4-(Benzyloxy)-3-fluorophenyl]boronic acid (5.00 g, 20 mmol) and cyclopentenone (0.85 mL, 10 mmol) were used and treated in a similar manner to (Step 1) of (Example 3) to give the title compound (1.95 g, 68%).

Workup

  1. additiontreated in a similar manner to (Step 1) of (Example 3)

Sources & evidence

ORD record
ord-71cfad530a1b43ccb2f53895e02ca02e
Source dataset
uspto-grants-2015_09
Patent number
US09133140B2

Reaction notes

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