Hydrochloric Acid → HCID 67296065, compound

Participants

Reaction Steps

{4-[(1R,3S)-3-{[(1R)-1-(4-Fluoronaphthalen-1-yl)ethyl]amino}cyclopentyl]phenoxy}acetic acid ethyl ester (800 mg, 1.8 mmol) was dissolved in ethanol (5 mL), followed by addition of 1N aqueous sodium hydroxide solution (5 mL), and the mixture was stirred for 30 minutes at room temperature. 1N hydrochloric acid was added dropwise to the reaction mixture to make the reaction solution acidic, and the solvent was distilled off under reduced pressure. The aqueous phase was extracted with chloroform, the extracted solution was dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure to give the title compound (742 mg, 99%).

Provenance & Evidence