Tert-butyl 2-(pyridin-3-yl)acetate → (R)-2-((R)-2-tert-Butoxy-2-oxo-1-(pyridin-3-yl)ethyl)-5,5,5-trifluoropentanoic acid

Participants

Reaction Steps

Intermediate S-3 was synthesized from tert-butyl 2-(pyridin-3-yl)acetate (100 mg, 0.517 mmol) and (R)-benzyl 5,5,5-trifluoro-2-(trifluoromethylsulfonyloxy)pentanoate (245 mg, 0.621 mmol) using the procedure described for Intermediate S-2 to give Intermediate S-3 (60 mg, 0.173 mmol) as a white solid containing about 30% of the (R, S) isomer. MS(ES):m/z=483.3 [M+H+].

Provenance & Evidence