Trifluoroacetic acid → HCID 57343391, compound

Participants

Reaction Steps

tert-Butyl-4-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-amido]piperidine-1-carboxylate (1 eq, 531 mg, 0.941 mmol) was stirred in dichloromethane (4 mL) and trifluoroacetic acid (1 mL) for 16 h. The reaction was concentrated in vacuo. The crude reaction material was then purified by silica gel column chromatography using 0-100% CMA 80/ethyl acetate to yield pure 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide (415 mg, 95%). 1H NMR (300 MHz, CHLOROFORM-d) d ppm 1.44 (qd, J=11.81, 3.86 Hz, 2H) 1.92-2.08 (m, 2H) 2.37 (s, 3H) 2.64-2.85 (m, 2H) 2.98-3.21 (m, 2H) 3.92-4.19 (m, 1H) 6.85 (d, J=8.29 Hz, 1H) 7.06 (d, J=8.38 Hz, 2H) 7.28 (s, 4H) 7.43 (s, 1H).

Provenance & Evidence