Sodium hydride → HCID 57343721, compound

Participants

Reaction Steps

To 4-nitrophenyl 4-[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-amido]piperidine-1-carboxylate (0.02 mmol, 1 eq.) and appropriate alcohol (0.5 mL) in THF (2 mL) was added sodium hydride 60% dispersion in mineral oil (4 mg, 0.1 mmol, 5 eq.). The reaction was stirred for 16 h and quenched with acetic acid. The reaction was concentrated in vacuo. The crude material was purified by column chromatography 0-100% ethyl acetate/hexanes to yield desired product.

Provenance & Evidence