Trifluoroacetic acid → HCID 71116108, compound

Participants

Reaction Steps

tert-Butyl N-(1-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]carbonyl}piperidin-4-yl)carbamate (194 mg) was stirred in dichloromethane (7 mL) and trifluoroacetic acid (3 mL) for 4 h. The reaction was concentrated in vacuo and dissolved in ethyl acetate. The solution was washed with 3.8 N NaOH and brine. The organic layer was dried with magnesium sulfate. The reaction was concentrated in vacuo to yield 0.15 g (94%) of desired product. 1H NMR (300 MHz, CHLOROFORM-d) δ ppm 1.31-1.52 (m, 2H) 1.83-2.02 (m, 2H) 2.14-2.26 (m, 3H) 2.84-3.07 (m, 2H) 3.11-3.33 (m, 1H) 4.31 (d, J=13.47 Hz, 1H) 4.66 (d, J=13.19 Hz, 1H) 7.07 (d, J=8.38 Hz, 2H) 7.14-7.20 (m, 1H) 7.21-7.34 (m, 3H) 7.44 (d, J=1.98 Hz, 1H); [M+H]+ 463.4.

Provenance & Evidence