HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-piperidinecarboxylate → HCID 68292124, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-piperidinecarboxylate | HCID 70770 | — |
| Reactant | HCID 86691112 | HCID 86691112 | — |
| Product | HCID 68292124 | HCID 68292124 | — |
| Product | 4-Piperidinecarboxylic acid, 1-[[4-(2,3-dihydro-1,4-benzodioxin-2-yl)phenyl]methyl]-, ethyl ester | HCID 68292126 | — |
| Product | HCID 68292341 | HCID 68292341 | — |
Reaction Steps
1-[4-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-benzyl]-piperidine-4-carboxylic acid ethyl ester is prepared from intermediate B and ethyl isonipecotate according to the procedure described in General Method B, and resolved by HPLC using a Chiralpak OD-H column, and eluting with 12% IPA in heptanes with 0.1% DEA to give (S)-1-[4-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzyl]-piperidine-4-carboxylic acid ethyl ester as the first-eluting peak, and (R)-1-[4-(2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzyl]-piperidine-4-carboxylic acid ethyl ester as the second-eluting peak.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133146B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-580c654066e140d2bc1525e26a1de4d5 |
| Source note | uspto-grants-2015_09 |