N-(tert-Butoxycarbonyl)-L-cyclohexylglycine → cyclopentyl (2S)-[(tert-butoxycarbonyl)amino](cyclohexyl)acetate

Participants

Reaction Steps

This was prepared in the same manner as (S)-2-benzyloxycarbonylamino-3-tert-butoxy-propionic acid cyclopentyl ester (Method A, Stage 1) but from (S)-tert-butoxycarbonylamino-cyclohexyl acetic acid. 1H NMR (300 MHz, CDCl3), δ: 1.00-1.40 (10H, m, CH×10), 1.45 (9H, s, C(CH3)3), 1.60-2.00 (8H, m, 4×CH2), 4.15 (1H, m, CH), 5.05 (1H, d, NH, J=7.6 Hz), 5.25 (1H, m, CH).

Provenance & Evidence