5-Nitroindazole → HCID 178526490, compound

HRID 227698Notes

Reaction equation

HRID 227698 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][N:8]=[CH:7]2)([O-:3])=[O:2].[Br:13]Br>CO>[Br:13][C:7]1[C:6]2[C:10](=[CH:11][CH:12]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)[NH:9][N:8]=1

Participants

4

Reactant 2

HCID 215015-NitroindazoleHCID 24408Bromine

Product 1

HCID 178526490HCID 178526490, compoundYield 112.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a stirred suspension of 5-Nitro-1H-indazole (15.0 g, 92.0 mmol) in 400 ml methanol was added bromine (4.7 ml, 92.0 mmol) dropwise at room temperature. The mixture was stirred at room temperature overnight. The solvent was evaporated to dryness to afford the title compound, (25.0 g, 100%); MS (ES+) m/e 243 [M+H]+.

Workup

  1. customThe solvent was evaporated to dryness

Sources & evidence

ORD record
ord-48ea08ab914d4746978e2661d811f3fa
Source dataset
uspto-grants-2009_07
Patent number
US07560467B2

Reaction notes

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