Nitrogen → HCID 15940510, compound

Participants

Reaction Steps

Compound (98) (21 mg, 0.043 mmol) was dissolved in THF (1 ml) and 2M NaOH (1 ml) added. The reaction vial was shaken for 16 h before THF removal by blowing a stream of N2 gas at the surface of the solution. The aqueous residue was purified by preparative HPLC to yield compound (99) (5.2 mg). LCMS purity 92%, m/z 422 [M++H]+, 1H NMR (400 MHz, MeOD), δ: 0.95-1.05 (6H, m, 2×CH3), 1.30-1.50 (4H, m, alkyl), 1.55-1.85 (7H, m, alkyl), 2.10 (2H, t, CH2), 2.40 (2H, t, CH2), 4.65 (1H, m, CH), 7.65 (2H, d, Ar), 7.80 (2H, d, Ar).

Provenance & Evidence