Urea → 4-(4-Fluorophenyl)-N-[3-(4-fluorophenyl)-1H-indazol-5-yl]-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide

Participants

Reaction Conditions

Reaction Steps

The product from Step (e) (0.3 g, 0.96 mmol), urea (87 mg, 1.44 mmol) and Ytterbium trifluoromethane (60 mg, 0.096 mmol) were combined In acetonitrile (2 ml) and 4-fluorobenzaldehyde (0.1 ml, 0.96 mmol) was added. The reaction mixture was sealed and heated to 100° C. for 3 hours. The reaction was diluted with water (1 ml) and the solid product was collected by filtration. The solid was washed three times with 1:1 Et2O/CH3CN. The crude was purified by silica gel chromatography eluting with 10% MeOH in CH2Cl2 to afford the title compound, (0.15 g, 34%); MS (ES+) m/e 460 [M+H]+.

Provenance & Evidence