Sodium Bicarbonate → HCID 68030291, compound

Participants

Reaction Steps

6-(4-((t-Butyldimethylsilyl)oxy)butyl)-4-hydroxy-3-propionyl-2H-pyran-2-one (XIV; 5 g; 14.1 mmol) in 150 ml AcOH/THF/water (3/1/1, v/v/v) was stirred at 28° C. for 18 h. The reaction mixture was neutralized with saturated NaHCO3, extracted with 3×150 ml EtOAc, dried with Na2SO4, and evaporated to an oil. The product was purified via silica chromatography (40% EtOAc in hexanes).

Provenance & Evidence