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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2277059Generated: November 1, 2026

Phenol → HCID 90404382, compound

https://huagongshe.com/reaction/2277059

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhenolHCID 996—
Reactant1-(tert-Butoxycarbonyl)-4-((p-toluenesulfonyloxy)methyl)piperidineHCID 10642851—
Reactant(R)-tert-butyl 3-hydroxy-3-(3-hydroxyphenyl)propylcarbamateHCID 90405310—
ProductHCID 90404382HCID 90404382—

Reaction Steps

Alkylation of phenol (7, Intermediate I) with tert-butyl 4-((tosyloxy)methyl)piperidine-1-carboxylate following the method used in Example 11 gave (R)-tert-butyl 4-((3-(3-((tert-butoxycarbonyl)amino)-1-hydroxypropyl)phenoxy)methyl)piperidine-1-carboxylate as a colorless oil. Yield (0.70 g, 80%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09133154B2
Source datasetuspto-grants-2015_09
ORD IDord-e08da3f8991f4978abf05871255c21c3
Source noteuspto-grants-2015_09