Phenol → HCID 67543885, compound

Participants

Reaction Steps

A mixture of tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate (1.91 g, 6.51 mmol), phenol (11) (1.25 g, 8.22 mmol), K2CO3 (1.11 g, 8.03 mmol) in anhydrous DMF (10 mL) was stirred under inert atmosphere at +80° C. for 18 hrs. The reaction mixture was partitioned between aqueous 25% NH4Cl and EtOAc. Aqueous layer was extracted with EtOAc and combined organic layers were washed with brine, dried over anhydrous MgSO4, and concentrated under reduced pressure to give tert-butyl 4-((3-(methoxycarbonyl)phenoxy)methyl)piperidine-1-carboxylate as a light yellow oil which was used in the next step without further purification. Yield (2.02 g, 89%).

Provenance & Evidence