HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → 4-[(3-Bromophenoxy)methyl]oxane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | 3-Bromophenol | HCID 11563 | — |
| Reactant | Oxan-4-ylmethyl methanesulfonate | HCID 15166436 | — |
| Reactant | (R)-tert-butyl 3-hydroxy-3-(3-hydroxyphenyl)propylcarbamate | HCID 90405310 | — |
| Product | 4-[(3-Bromophenoxy)methyl]oxane | HCID 53211272 | — |
Reaction Steps
Alkylation of 3-bromophenol with (tetrahydro-2H-pyran-4-yl)methyl methanesulfonate following the method used in preparation of phenol (7, Intermediate I) gave 4-((3-bromophenoxy)methyl)tetrahydro-2H-pyran as a white solid which was used in the next step without additional purification. Yield (quant.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133154B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-138b4a3726774b85b4abff7e1945b2de |
| Source note | uspto-grants-2015_09 |