6-Oxopiperidine-3-carboxylic acid → HCID 131733448, compound

HRID 2277080Notes

Reaction equation

HRID 2277080 reaction equation
[O:1]=[C:2]1[NH:7][CH2:6][CH:5]([C:8]([OH:10])=O)[CH2:4][CH2:3]1.[NH2:11][C:12]1[CH:13]=[C:14]([CH:18]([OH:29])[CH2:19][CH2:20][NH:21][C:22](=[O:28])[O:23][C:24]([CH3:27])([CH3:26])[CH3:25])[CH:15]=[CH:16][CH:17]=1>>[OH:29][CH:18]([C:14]1[CH:15]=[CH:16][CH:17]=[C:12]([NH:11][C:8]([CH:5]2[CH2:4][CH2:3][C:2](=[O:1])[NH:7][CH2:6]2)=[O:10])[CH:13]=1)[CH2:19][CH2:20][NH:21][C:22](=[O:28])[O:23][C:24]([CH3:27])([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 5600906-Oxopiperidine-3-carboxylic acidHCID 68525292HCID 68525292, compound

Product 1

HCID 131733448HCID 131733448, compound

Procedure

Condensation between 6-oxopiperidine-3-carboxylic acid and tert-butyl (3-(3-aminophenyl)-3-hydroxypropyl)carbamate gives tert-butyl (3-hydroxy-3-(3-(6-oxopiperidine-3-carboxamido)phenyl)propyl)carbamate.

Sources & evidence

ORD record
ord-57a61f8f272e4ca9905c0b5de2e83617
Source dataset
uspto-grants-2015_09
Patent number
US09133154B2

Reaction notes

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