Phenol → HCID 131733449, compound

HRID 2277081Notes

Reaction equation

HRID 2277081 reaction equation
CS([O:5][CH2:6][CH:7]1[CH2:12][CH2:11][N:10]([S:13]([CH3:16])(=[O:15])=[O:14])[CH2:9][CH2:8]1)(=O)=O.C1(O)C=CC=CC=1.[OH:24][C@@H:25]([C:36]1[CH:41]=[CH:40][CH:39]=[C:38](O)[CH:37]=1)[CH2:26][CH2:27][NH:28][C:29](=[O:35])[O:30][C:31]([CH3:34])([CH3:33])[CH3:32]>>[OH:24][C@@H:25]([C:36]1[CH:37]=[CH:38][CH:39]=[C:40]([O:5][CH2:6][CH:7]2[CH2:12][CH2:11][N:10]([S:13]([CH3:16])(=[O:15])=[O:14])[CH2:9][CH2:8]2)[CH:41]=1)[CH2:26][CH2:27][NH:28][C:29](=[O:35])[O:30][C:31]([CH3:34])([CH3:33])[CH3:32]

Participants

4

Reactant 3

HCID 996PhenolHCID 86603949HCID 86603949, compoundHCID 90405310(R)-tert-butyl 3-hydroxy-3-(3-hydroxyphenyl)propylcarbamate

Product 1

HCID 131733449HCID 131733449, compound

Procedure

Reaction between (1-(methylsulfonyl)piperidin-4-yl)methyl methanesulfonate and phenol (7, Intermediate I) gives (R)-tert-butyl (3-hydroxy-3-(3-((1-(methylsulfonyl)piperidin-4-yl)methoxy)phenyl)propyl)carbamate.

Sources & evidence

ORD record
ord-9aa828355b6f49adb4c58478aa7650ac
Source dataset
uspto-grants-2015_09
Patent number
US09133154B2

Reaction notes

Loading…