Piperidine → HCID 89835603, compound

Participants

Reaction Steps

Piperidine (1.0 mL, 10.0 mmol) was added dropwise to a stirred solution of (S)-{9H-Fluoren-9-yl)methyl-2-[2-{(tert-butoxycarbonylamino)methyl}-5-chlorobenzylcarbamoyl]piperidine-1-carboxylate (0.89 g, 1.47 mmol) in CH2Cl2 (5 mL). The reaction mixture was stirred at room temperature for 1 h. Solvent was removed under reduced pressure and the crude product was purified by reverse phase combiflash column chromatography (C18; eluent: 10-100% acetonitrile:water) to afford the title compound (0.45 g) as a white solid.

Provenance & Evidence