Piperidine → HCID 89835592, compound

Participants

Reaction Steps

Piperidine (4.5 mL, 45.2 mmol) was added to a solution of (S)-(9H-Fluoren-9-yl)methyl-3-{(2-[{(tert-butoxycarbonyl)amino}methyl]-5-chlorobenzyl}carbamoyl]morpholine-4-carboxylate (4.10 g, 67.6 mmol) in CH2Cl2 (20 mL) at 0° C. and the reaction mixture was stirred at room temperature for 1 h. The reaction mixture was concentrated to dryness and the residue was purified by reverse phase combiflash chromatography (C18; 10-100% acetonitrile/water) to afford the title compound as a white solid (1.61 g).

Provenance & Evidence